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Immunotherapy's evolving role in cancer treatment

  • 07.21.2015

Immunotherapy's evolving role in cancer treatment

cancer survivor

What is immunotherapy?

Immunotherapy is treatment that uses parts of a person's immune system to fight diseases such as cancer. Also called biologic therapy or biotherapy, this form of cancer treatment works by stimulating a person's own immune system to work harder or smarter to attack cancer cells or by supplementing the immune system with man-made immune system proteins.

How is immunotherapy used to prevent and treat cancer?

While chemotherapy is still widely  viewed as the most effective cancer fighting tool, in the last few decades, immunotherapy has become an important part of treating some types of cancer. Three main types of immunotherapy are now being used to treat cancer, including:

(1) MONOCLONAL ANTIBODIES

Monoclonal antibodies are given intravenously. The antibodies themselves are proteins, so giving them can sometimes cause something like an allergic reaction.

Examples include:

  • Alemtuzumab (Campath®) is used to treat chronic lymphocytic leukemia. It binds to cancer cells and attracts immune cells to destroy the cancer.
  • Trastuzumab (Herceptin®) is used to fight cancers where cells have large amounts of the HER2 protein on their surface, including breast and stomach. Trastuzumab binds to these proteins and stops them from becoming active.
  • Ibritumomab tiuxetan (Zevalin®) is an antibody that delivers radioactivity directly to cancerous B cells and can be used to treat some types of non-Hodgkin lymphoma.
Brentuximab vedoti (Adcetris®) is used to treat Hodgkin lymphoma and anaplastic large cell lymphoma that is no longer responding to other treatments.
  • Ado-trastuzumab emtansine (Kadcyla®) is used to treat advanced breast cancer in patients whose cancer cells have too much HER2.
  • Denileukin diftitox (Ontak®) is used to treat lymphoma of the skin and is being studied for use against a number of other cancers.

American Cancer Society recommendations for early breast cancer detection

  • Women age 40 and older should have a screening mammogram every year.
  • Women in their 20s and 30s should have a clinical breast exam as part of a regular health exam by a health professional, at least every 3 years.
  • Breast self-exam is an option for women starting in their 20s
  • Women at high risk (greater that 20% lifetime risk) based on certain risk factors (see above) should get an MRI and a mammogram every year.

(2) CANCER  VACCINES

Cancer vaccines are put into the body to start an immune response against certain diseases and help prevent or treat cancer.

Prevention

Prevention vaccines target the viruses that can cause certain cancers and are only useful for cancers known to be caused by infections.

  • HPV - Strains of the human papilloma virus (HPV) have been linked to cervical, anal, throat, and other cancers. Vaccines against HPV may help protect against some of these cancers when administered to boys and girls between the ages of 11 and 12.
  • HBV - People who have chronic infections with the hepatitis B virus (HBV) are at higher risk for liver cancer. Getting the vaccine to help prevent HBV infection may therefore lower some people's risk of getting liver cancer. Children should receive vaccination series at 6 to 18 months.

Treatment

These vaccines are designed to get the immune system to attack a disease that already exists with one or more specific antigens. Because the immune system  has special cells for memory, it's hoped that the vaccine might continue to work long after it's given.

  • Sipuleucel-T (Provenge®) is the only vaccine approved so far by the US Food and Drug Administration to treat cancer. It is used to treat advanced prostate cancer that is no longer being helped by hormone therapy.

Although the vaccine doesn't cure prostate cancer, it has been shown to help extend patient's lives by several months on average.

(3) NON-SPECIFIC  IMMUNOTHERAPIES

Non-specific immunotherapies boost the immune system in a general way, but they  can also help the immune system attack cancer cells. 

  • Interleukin-2 is a chemical made by immune cells and is approved to treat advanced kidney cancer and metastatic melanoma.
  • Interferon IFN-alfa is another chemical made by immune cells that is approved  to treat hairy cell leukemia, chronic myelogenous leukemia, follicular non-Hodgkin lymphoma, cutaneous (skin) T-cell lymphoma, kidney cancer, melanoma, and kaposi sarcoma.
  • A man-made version of granulocyte-macrophage colony-stimulating factor (GM-CSF), known as sargramostim (Leukine®), is often used to boost white blood cell counts after chemotherapy.
  • Ipilimumab (Yervoy®) is an antibody used to treat melanoma that can't be removed by surgery or has spread.
  • Pembrolizumab (Keytruda) is an antibody that blocks PD-1 that has recently been approved to treat advanced melanoma.
  • Thalidomide (Thalomid®), lenalidomide (Revlimid®), and pomalidomide (Pomalyst®) are immunomodulating drugs that boost the immune system and are used to treat multiple myeloma.
  • Bacille Calmette-Guérin is a germ that infects human tissues and helps activate the immune system and is FDA-approved for early stage bladder cancer.
  • Imiquimod (Zyclara®) is applied as a cream to stimulate an immune response against skin cancer cells in very early stage skin cancers.
hepatitis B virus

Sources: www.cancer.org

Johannes Gutenberg Universitaet Mainz. "Significant progress made towards individualized cancer immunotherapy." ScienceDaily. ScienceDaily, 12 May 2015.

www.sciencedaily.com/releases/2015/05/150512104030.htm.

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